Following their successful and fun learning activities at the “Science in the City” Festival in Toulouse, Universidad Autónoma de Madrid (UAM) has been invited to the “European Night of Researchers” in Zaragoza, on Sept 28th 2018.
This will be another great opportunity to demonstrate to the public exciting research conducted within the EU funded innovative biotechnology projects CarbaZymes and MetaFluidics, in which UAM is an active partner.
Everyone is welcome to learn about and test those superpowers!

This research work was also presented as a poster at the Spanish Society for Microbiology conference on Teaching and Dissemination of Microbiology in Madrid in July, where it was awarded first prize. Jorge Bravo, MSc received the prize on behalf of CarbaZymes, MetaFluidics and UAM (pictured).

You can download the winning poster here: Available in English and in Spanish.


Our partner Enzymicals will be present at the CPhI Worldwide in Madrid next October 9th to 11th

CPhI Worldwide, together with co-located events ICSE, InnoPack, P-MEC and FDF, hosts more than 45,000 visiting pharma professionals over three days. 2,500+ exhibitors from 153 countries gather at the event to network and take advantage of more than 150 free industry seminars.

Enzymicals is please to invite you to visit their stand No 3J16 at CPHI.

See you in Madrid.

Since 2002 the International Congress on Biocatalysis (BIOCAT) has been organized as a biennial congress, focused on the rapidly evolving fields of biocatalysis and industrial biotechnology. In August 26 to 30 2018 its 9th edition will be hosted in  Hamburg, Germany. The appeal and impact of Biocat is very significant for the biocatalysis community: for example the 2016 edition attracted more than 2900 participants from over 40 countries.

The major topics to be addressed this year are:

  • Enzyme discovery, production and application
  • Structure-function analysis and enzyme design
  • Enzymatic and whole cell biotransformations
  • Bioprocess engineering and downstream processing
  • Sustainable industrial processes, biorefinery and bioeconomy

The conference´s topics are very much in line with the objectives of CarbaZymes project!

Therefore click here if you don't want to miss it! 


August 27th 2018

14:30–16:30       Poster session 1 – Topic 3: Enzymatic and whole cell biotransformations
Room H0.01-H0.09         

  • P3-2:  Aldol additions of pyruvate analogs to formaldehyde: synthesis of optically active β-hydroxycarboxylic esters.
                Karel Hernández (CSIC).
  • P3-9:  Model optimization of DERA-catalyzed double aldol addition.
                Ana Vrsalović Presečki (UZAG).
  • P3-31: Mathematical modeling of DERA-catalyzed statin side-chain intermediate production.
                  Anera Švarc (UZAG).

August 29th 2018

14:30–16:30       Poster session 3: Structure-function analysis and enzyme design                            
                           Room H0.01-H0.09         

  • P2-28  Thermostabilization of a new halohydrin dehalogenase by protein engineering.            
                 Julia Koopmeiners (TUBS).
  • P2-22  Thermostabilization of the pyruvate aldolase YfaU using an enhanced folding reporter
    Sandra Bosch (UAM)

14:30–16:30       Poster session 3: Bioprocess engineering and downstream processing
Room H0.01-H0.09         

  • P4-14  Scale-up of a novel aldolase approach to produce statin side chain API intermediate.
                 Melinda Fekete (ENZ).

August 30th 2018

Industrial implementations, Morning session 5 – Topic 3: Enzymatic and whole cell biotransformations (Room Audimax I)

11:20–11:40       L3-8      Selective ring-opening of di-substituted epoxides by halohydrin dehalogenases. 
                                            Anett Schallmey (TUBS).

YES, Proteins and Microbes do have Superpowers!!


Hundreds of children and adults took part and had fun while learning about microbes in the Science in the City Festival  in Toulouse, France.


From July 9th to July 12th, partners from CarbaZymes and MetaFluidics were present in Toulouse for the “Science in the City Festival”, the general public event of the EuroScience Open Forum (ESOF) Congress. For 4 days on the Place du Capitole, children and adults could discover the many different uses of microbes and proteins in our daily life as part of the « Proteins and Microbes with Superpowers » activities, co-organised by Horizon 2020-funded projects MetaFluidics and Carbazymes.

To begin with, after being briefed on what we, as scientists, do in Carbazymes and MetaFluidics , children and adults were invited to join our microbiology team to go and explore the environment in search for microbes with specific characteristics. The “environment” as such was represented by a ball pool, which was very much appreciated by all visitors (as well as the scientists involved! :-)).


After finding the super microbes, participants continued their mission by carrying out different experiments involving microorganisms. The message was clear: “Whatever you do in your daily life, microbes are involved!”. Visitors could for instance learn about the superpowers that the bacteria in our bodies have by identifying where the “good” and the “bad” microbes are: in our skin, in our mouth, in our lungs, in our stomach, in our gut, in our blood…

They also learned about how microbes are useful in preparing and preserving some very tasty food products like cheese, bread, wine, and mimicked the use of microbes in several depollution processes.

And last but not least, adult visitors learned that all these microbial abilities are due to the efficient production of a battery of enzymes with superpowers: They were introduced to how cells decode DNA and how enzymes can be synthesised at large scales to help us live better!



In total, nearly 400 persons (both adults and children) visited our stand on Place du Capitole. Despite the warm weather, everyone thoroughly enjoyed exchanging and communicating about microbiology with the general public, including children of all ages who may one day join the scientific community for real!

This article has been extracted from the Metafluidics news page.



The European Federation of Biotechnology (EFB) is Europe’s non-profit federation of National Biotechnology Associations, Learned Societies, Universities, Scientific Institutes, Biotech Companies and individual biotechnologists working to promote biotechnology throughout Europe and beyond. As the independent “Voice of Biotechnology in Europe”, EFB promotes the safe, sustainable and beneficial use of fundamental research and innovation in life sciences, while providing a forum for interdisciplinary and international cooperation.

EFB organizes a major congress every two years, with the Geneva 2018 venue marking its 18th edition CarbaZymes partners from the University of Zagreb participated with a strong team presenting three posters highlighting the advances of the Carbazymes research, below: 


Morana Česnik

Mathematical model based optimization of enzymatic aldol addition of propanal to formaldehyde.

The mathematical model of the aldol addition of propanal to formaldehyde was used to optimize the reaction conditions in the fed-batch reactor. At the optimal process conditions after 5.5 hours product concentration was 814 mmol dm-3  (72 g L–1), product yield was 88.5% and volume productivity was 313.7 g L–1 d–1.


Zvjezdana Findrik Blažević

Chemical engineering methodology in process development: a case study of MenD-catalyzed 1,4 addition of a-ketoglutaric acid to acrylonitirile.

The poster shows how process model based on reliable kinetic data can be used for process optimization as well as a sound basis for preliminary calculation of process costs. The work presented showed that the process is profitable at the most probable product 6-cyano-4-oxohexanoic acid price.  


Martina Sudar

Kinetic characterization of enzymes in a multi-enzyme cascade reaction to the synthesis of statin side-chain precursors. .

The poster presents the development of the mathematical model of the cascade reaction towards the statin side-chain precursors which will later be used for process optimisation.


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