6th NovelEnzymes
October 9 – 12, 2018
Darmstadt, Germany


The 6th Novel Enzymes conference will take place at the Technische Universitaet Darmstadt, Germany, in the old "Maschinenhaus“ from 9 – 12 October 2018.

The main topics of the conference series are current developments in catalysis research using enzymes. Enzymes are natural biocatalysts that enable energy-efficient and environmentally friendly transformations of chemical compounds, thus enabling the development of sustainable production processes for the chemical and pharmaceutical industries. Applied biocatalysis in biotechnology, which is viewed as a key technology for the 21st century, has a high potential for improving the quality of human life and for a global societal impact. Biocatalyis will facilitate the shift from fossil resources towards a low-carbon economy, thus securing the material supply for future generations.

The Novel Enzymes conference brings together more than 200 leading scientists from universities, research institutes and the industry to share their latest findings and developments in the discovery and engineering of novel enzymes. The conference is organized by Wolf-Dieter Fessner, Professor of Bio-Organic Chemistry at the Department of Chemistry of the TU Darmstadt. Emphasizing the highly topical significance of this conference, he said: "The awarding of the Nobel Prize for Chemistry 2018 to the US American scientist Frances Arnold from the California Institute of Technology for her development of groundbreaking methods in creating novel and improved enzymes, is a strong acknowledgment of the great significance of this research area for the future of our planet. Professor Arnold was honored with the Emanuel Merck Lectureship Award in 2013, presented jointly with Merck at the TU Darmstadt. We are extremely pleased for the recognition of her work, which has also significantly benefited our own research.” Professor Fessner is currently coordinating research in two European collaborative projects: CarbaZymes and Tralaminol (14 and 6 partners respectively), which are EU-funded with over 13 million euros, to develop advanced, integrated production processes for the enzyme-catalyzed production of valuable components for active pharmaceutical ingredients, fine chemicals and bulk materials. The Novel Enzymes conference is an important platform to present and discuss the recent results of these projects with experts in the biocatalysis field.

For further information:





Following their successful and fun learning activities at the “Science in the City” Festival in Toulouse, Universidad Autónoma de Madrid (UAM) has been invited to the “European Night of Researchers” in Zaragoza, on Sept 28th 2018.
This will be another great opportunity to demonstrate to the public exciting research conducted within the EU funded innovative biotechnology projects CarbaZymes and MetaFluidics, in which UAM is an active partner.
Everyone is welcome to learn about and test those superpowers!

This research work was also presented as a poster at the Spanish Society for Microbiology conference on Teaching and Dissemination of Microbiology in Madrid in July, where it was awarded first prize. Jorge Bravo, MSc received the prize on behalf of CarbaZymes, MetaFluidics and UAM (pictured).

You can download the winning poster here: Available in English and in Spanish.


Our partner Enzymicals will be present at the CPhI Worldwide in Madrid next October 9th to 11th

CPhI Worldwide, together with co-located events ICSE, InnoPack, P-MEC and FDF, hosts more than 45,000 visiting pharma professionals over three days. 2,500+ exhibitors from 153 countries gather at the event to network and take advantage of more than 150 free industry seminars.

Enzymicals is please to invite you to visit their stand No 3J16 at CPHI.

See you in Madrid.

Since 2002 the International Congress on Biocatalysis (BIOCAT) has been organized as a biennial congress, focused on the rapidly evolving fields of biocatalysis and industrial biotechnology. In August 26 to 30 2018 its 9th edition will be hosted in  Hamburg, Germany. The appeal and impact of Biocat is very significant for the biocatalysis community: for example the 2016 edition attracted more than 2900 participants from over 40 countries.

The major topics to be addressed this year are:

  • Enzyme discovery, production and application
  • Structure-function analysis and enzyme design
  • Enzymatic and whole cell biotransformations
  • Bioprocess engineering and downstream processing
  • Sustainable industrial processes, biorefinery and bioeconomy

The conference´s topics are very much in line with the objectives of CarbaZymes project!

Therefore click here if you don't want to miss it! 


August 27th 2018

14:30–16:30       Poster session 1 – Topic 3: Enzymatic and whole cell biotransformations
Room H0.01-H0.09         

  • P3-2:  Aldol additions of pyruvate analogs to formaldehyde: synthesis of optically active β-hydroxycarboxylic esters.
                Karel Hernández (CSIC).
  • P3-9:  Model optimization of DERA-catalyzed double aldol addition.
                Ana Vrsalović Presečki (UZAG).
  • P3-31: Mathematical modeling of DERA-catalyzed statin side-chain intermediate production.
                  Anera Švarc (UZAG).

August 29th 2018

14:30–16:30       Poster session 3: Structure-function analysis and enzyme design                            
                           Room H0.01-H0.09         

  • P2-28  Thermostabilization of a new halohydrin dehalogenase by protein engineering.            
                 Julia Koopmeiners (TUBS).
  • P2-22  Thermostabilization of the pyruvate aldolase YfaU using an enhanced folding reporter
    Sandra Bosch (UAM)

14:30–16:30       Poster session 3: Bioprocess engineering and downstream processing
Room H0.01-H0.09         

  • P4-14  Scale-up of a novel aldolase approach to produce statin side chain API intermediate.
                 Melinda Fekete (ENZ).

August 30th 2018

Industrial implementations, Morning session 5 – Topic 3: Enzymatic and whole cell biotransformations (Room Audimax I)

11:20–11:40       L3-8      Selective ring-opening of di-substituted epoxides by halohydrin dehalogenases. 
                                            Anett Schallmey (TUBS).

YES, Proteins and Microbes do have Superpowers!!


Hundreds of children and adults took part and had fun while learning about microbes in the Science in the City Festival  in Toulouse, France.


From July 9th to July 12th, partners from CarbaZymes and MetaFluidics were present in Toulouse for the “Science in the City Festival”, the general public event of the EuroScience Open Forum (ESOF) Congress. For 4 days on the Place du Capitole, children and adults could discover the many different uses of microbes and proteins in our daily life as part of the « Proteins and Microbes with Superpowers » activities, co-organised by Horizon 2020-funded projects MetaFluidics and Carbazymes.

To begin with, after being briefed on what we, as scientists, do in Carbazymes and MetaFluidics , children and adults were invited to join our microbiology team to go and explore the environment in search for microbes with specific characteristics. The “environment” as such was represented by a ball pool, which was very much appreciated by all visitors (as well as the scientists involved! :-)).


After finding the super microbes, participants continued their mission by carrying out different experiments involving microorganisms. The message was clear: “Whatever you do in your daily life, microbes are involved!”. Visitors could for instance learn about the superpowers that the bacteria in our bodies have by identifying where the “good” and the “bad” microbes are: in our skin, in our mouth, in our lungs, in our stomach, in our gut, in our blood…

They also learned about how microbes are useful in preparing and preserving some very tasty food products like cheese, bread, wine, and mimicked the use of microbes in several depollution processes.

And last but not least, adult visitors learned that all these microbial abilities are due to the efficient production of a battery of enzymes with superpowers: They were introduced to how cells decode DNA and how enzymes can be synthesised at large scales to help us live better!



In total, nearly 400 persons (both adults and children) visited our stand on Place du Capitole. Despite the warm weather, everyone thoroughly enjoyed exchanging and communicating about microbiology with the general public, including children of all ages who may one day join the scientific community for real!

This article has been extracted from the Metafluidics news page.


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