The University of Groningen (RUG, founded in 1614) is among the global elite with a classification in the top 100 of the most influential ranking lists in the academic world. RUG has extended education and research activities in all major academic disciplines, including a strong research program in the life sciences/biotechnology area.

According to the German Centre for Higher Education, the University of Groningen is a member of the so-called Excellence Group of best 56 universities in Europe (out of ~4500 European institutions) in five of seven investigated disciplines, including Biology and Chemistry.

RUG Link: http://www.rug.nl/

Role in the project

The Pharmaceutical Biotechnology group involved in the CARBAZYMES project has a strong international position in the area of enzyme discovery, characterization, promiscuity, engineering, and catalysis. Currently, the group has an innovative research program on lyases, oxygenases, and proline-based tautomerases.

The group solved X-ray structures, catalytic mechanisms, and the basis of enantioselectivity of these enzymes, performed protein engineering studies aimed at improving their catalytic properties, and developed new biocatalytic conversions (C-N and C-C bond-formation) with these enzymes.

This group is undertaking the engineering of highly active variants of a specific family of enzymes for the development of a key product, as well as the development of optimized variants with both enhanced activity and stability, immobilization of the best variants and analysis of the efficiency of the enzyme recovery and re-use.

The Poelarends' Group Link: http://www.rug.nl/staff/g.j.poelarends/

Contributors to CARBAZYMES

 Prof. Gerrit J. Poelarends

 Principal Investigator

 Mr. Lieuwe Biewenga

 PhD Student

 Mr. Guo Chao

 PhD Student

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